The opening shots of the moors are near Hay, a mountain that straddles the Welsh border in Brecon Beacons National Park. The scenes were shot on the Welsh side of Hay Bluff, about four miles to the south of the town of Hay-on-Wye in the county of Powys. The scene where David and Jack get dropped off by the sheep farmer is by the stone circle, the same location where, later in the film, Dr. Hirsch stops and looks at the sign for East Proctor. The same road provides the scenery for the next two shots, where David and Jack talk about Debbie Klein.

 

East Proctor was filmed at  a small hamlet ten miles to the west of Hay Bluff called Crickadarn. It is featured from the shot where David and Jack walk down a hill towards East Proctor. The exterior of the "Slaughtered Lamb" was a private house in Crickadarn dressed to look like a pub and the Angel of Death statue in the village was a prop created by the movie makers. The church next door is also still frequented, however the upper levels have now fallen into disrepair.

 

The interior of the "Slaughtered Lamb" was filmed in a pub called The Black Swan, Ockham, Surrey near Effingham. The bar was used but a false wall was built to make the pub look smaller. The Black Swan was re-furbished and extended to become a gastro pub in 2006 making it unrecognisable from the interior used for the film.

 

Nurse Alex's flat is located on Coleherne Road, just off Redcliffe Square (SW10), Kensington near to Earl's Court. 

 

The attack at the tube station was set in — and filmed at — Tottenham Court Road tube station although the chase through the tunnels of the station was actually filmed at Charing Cross tube station. During the tunnel scene posters advertising "See you next Wednesday" can clearly be seen on the tunnel walls. This is the movie which Jack asks David to go to confront his victims from the previous night, and is an in-joke featuring in many John Landis movies. 

 

Piccadilly Circus is a famously busy intersection and tourist area in central London, and was completely closed down for the production, but only for a few minutes at a time! Director John Landis recalls:
"I got two February nights, between 1am and 4am and was allowed to stop traffic three times, for two minutes maximum. So we rebuilt the Circus off-site and rehearsed the big crash scene many times and my crew were drilled like a Formula One team, so when it came to the big bus crash we could clear it up and do another take in seconds. Vic Armstrong, who was the bus driver, went on to design many of the James Bond stunts. Boy, we worked fast." (from interview The Guardian, 29 August 2009) 

 

The final sequence in the alleyway was filmed at Clink Street, London. The location is now almost unrecognisable, the area having been redeveloped since.

 

The scenes where David wakes up naked in the zoo were shot at London Zoo, Regent's Park.

 

Remaining interiors, including the still jaw-dropping transformation scene, were shot at Twickenham Studios.